核心要点
- 问题/背景
- 这篇 Neuron 论文研究历史依赖决策中内部表征如何被维持和更新。作者在小鼠中结合多脑区单神经元记录与光遗传，发现 PPC-PUL 高阶丘脑-皮层网络维持 sensory-history representations，而近期统计模式变化会调动 TRN 对 PUL 的抑制控制，促进表征更新。它值得收录，因为它给出 representation stabilization 与 update gating 的具体回路分工，对动态上下文、预...
原始摘要与中文对照
中文对照翻译
当感觉信息模糊时，我们必须根据由我们以往经验构建的表征来解释当前的输入。尽管适当地更新这种内部表征以追踪环境变化对行为至关重要，但这种动态整合的神经基础仍然未知。通过结合在行为和被动条件下对小鼠进行的多区域单细胞记录和光遗传学技术，我们发现后顶叶皮层 (PPC) 及其高阶丘脑对应物丘脑枕 (PUL) 之间的相互作用对于稳定维持基于感觉历史的决策表征是必需的。我们还发现了一种机制，即近期感觉经验中统计模式的变化会通过丘脑网状核 (TRN) 对丘脑枕 (PUL) 进行抑制性控制，从而促进编码感觉历史的更新。我们的结果建立了一个框架，其中丘脑和皮层中的互补操作协同作用，使内部表征能够适应性地追踪不断变化的条件。
原始摘要
When sensory information is ambiguous, we must interpret current inputs based on a representation con structed from our previous experiences. Although appropriately updating this internal representation to track environmental changes is essential for behavior, the neural basis of this dynamic integration remains un known. Using a combination of multi-area single-unit recordings and optogenetic techniques in mice under both behavioral and passive conditions, we find that interactions between the posterior parietal cortex (PPC) and its higher-order thalamic counterpart, the pulvinar (PUL), are necessary to stably maintain representa tions underlying decision-making based on sensory history. We also identify a mechanism by which shifts in statistical patterns across recent sensory experiences engage inhibitory control of the PUL by the thalamic reticular nucleus (TRN) to facilitate the updating of encoded sensory history. Our results establish a frame work in which complementary operations in the thalamus and cortex act in concert to allow internal represen tations to adaptively track changing conditions.