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Brain activity, disruption and connectivity comparisons identify origins of human metacognition in other primates

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This Nature Human Behaviour paper investigates the evolutionary and neural origins of prospective metacognition by comparing humans and macaques across behaviour, brain activity, disruption, and connectivity. The study identifies complementary activity patterns in macaque ventrolateral prefrontal areas 45a and 47/12o, and uses ultrasonic disruption to test causal contributions of these areas to prospective decision simulation. A comparative connectivity analysis links the conjunction of these macaque circuits to the human anterior lateral prefrontal region associated with sophisticated metacognitive planning. For this repository, the value is conceptual but strong: it clarifies neural circuit origins of metacognitive monitoring and prospective self-simulation, a core framing for AI agents that need self-evaluation, uncertainty awareness, and planning over their own future behavior.

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